Prof. Dr. Emel Akoğlu
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Andrology & Men's Health
Prp with ha for peyronie's disease
What PRP with hyaluronic acid injections for Peyronie's disease involve, how they are meant to work on the plaque, what the evidence does and does not show, how they compare with collagenase, traction and surgery, approximate costs in Turkey against the UK, US and Germany, sessions, recovery, risks and how to check a clinic.
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Prof. Dr. Zerrin Biçik Bahçebaşı
UrologyVerified
- 37+years exp.
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What is PRP with HA for Peyronie's disease, and how is it meant to work?
PRP with HA for Peyronie's disease is an injection treatment that combines platelet-rich plasma (PRP) with hyaluronic acid (HA) and places it in or around the scar-like plaque that causes penile curvature. PRP is made from a sample of your own blood spun in a centrifuge to concentrate platelets, which release growth factors involved in tissue repair. Hyaluronic acid is a gel-like substance found naturally in tissue. The idea is that the mixture may soften the plaque, reduce inflammation and help the tissue remodel, so that curvature, pain or hard areas improve. It is an emerging, off-label approach, not a standard of care.
This guide explains how the treatment is done, what the evidence does and does not show, who may be considered, what it costs in Turkey compared with the UK, US and Germany, what to expect afterwards and how to check a clinic. For other options see our urology treatments in Turkey.
What is Peyronie's disease, and which part does PRP target?
Peyronie's disease is a build-up of fibrous scar tissue (a plaque) in the tunica albuginea, the sheath around the erectile tissue. It can cause a curve or bend in the erection, pain, a palpable lump, narrowing or shortening, and sometimes erection difficulty. It has two phases: an active phase, usually the first twelve to eighteen months, when pain and change are possible, and a stable phase, when the curve no longer changes. PRP with HA is aimed at the plaque and the surrounding inflammation, and a urologist should confirm the diagnosis, phase and curvature with an examination and, if needed, an ultrasound before any injection.
Does PRP with HA work for Peyronie's disease? What the evidence shows
The honest answer is that evidence is limited. Small studies and case series suggest that PRP injections, alone or with other treatments, may improve pain, plaque size and curvature in some men, but these studies are small, vary in method and often lack a control group. Large, well-controlled trials are missing, so professional bodies such as the American Urological Association (AUA) and the European Association of Urology (EAU) do not list PRP as a standard treatment. Hyaluronic acid alone has even less supporting data. This means that results are uncertain and cannot be promised. A reliable clinic will describe it as an option with limited evidence, not as a cure, and will tell you about established alternatives.
PRP with HA, collagenase, traction or surgery: how do they compare?
Established treatments for stable disease with a significant curve include collagenase clostridium histolyticum injections (approved by the FDA for curvature over 30 degrees with a palpable plaque), and surgery. Penile traction devices are used in some programmes, with modest evidence. Surgery has the most reliable effect on curvature in the stable phase, and is explained in our guide to Peyronie's disease surgery.
| Option | Best suited to | Typical limits |
|---|---|---|
| PRP with HA | Mild to moderate curvature, pain or plaque; patients wanting a minimally invasive try | Limited evidence; results uncertain; several sessions |
| Collagenase injections | Stable curvature over about 30 degrees with a palpable plaque | Bruising, rare penile fracture; a course of injections and modelling |
| Surgery (plication, grafting, implant) | Stable, significant curvature or erectile failure | Operation risks; possible shortening or numbness |
A urologist should explain why they suggest one of these and what happens if the injections do not help.
PRP with HA for Peyronie's disease: cost in Turkey compared with the UK, US and Germany
The figures below are approximate ranges per treatment session, not hospital quotes. The total depends on the number of sessions, which is set by the clinic's protocol, and the hospital confirms its price in a written quote.
| Country | Approximate cost range per session |
|---|---|
| Turkey | €300 – €1,500 |
| United Kingdom | €600 – €2,500 |
| United States | €1,000 – €4,000 |
| Germany | €600 – €2,500 |
What changes the price: the number of sessions, whether PRP is used alone or with HA, the kit and the volume of blood drawn, the assessment and ultrasound, and any additional treatment such as traction. A package may include the consultation, blood draw, injection and follow-up; ask whether one price covers the whole course and whether follow-up visits at home are needed.
Who may be a candidate for PRP with HA, and who is not?
PRP with HA is usually considered for men with a confirmed Peyronie's plaque, mild to moderate curvature or penile pain, who want a non-surgical option and understand that results are uncertain. It is not suitable if you have a blood-clotting disorder or platelet disease, are taking anticoagulants that cannot be paused, have an infection or skin lesion at the site, or have a history of an allergic reaction to a component. It is not a replacement for surgery when the curve is severe, the erect penis cannot be used for sex, or when erection failure is the main problem; in that case a penile prosthesis may be discussed.
How is the treatment done? Step by step
You are examined, the plaque is mapped and the curvature may be measured after an injection that induces an erection, or from your own photographs. A small blood sample is taken, spun in a centrifuge for several minutes and the plasma is prepared with hyaluronic acid. The skin is cleaned and numbed with a local anaesthetic, and the mixture is injected into and around the plaque with a fine needle, sometimes guided by ultrasound. The visit usually takes less than an hour. Clinics often recommend a course of several sessions spaced weeks apart, and some combine the injections with traction or vacuum devices, although protocols vary and there is no agreed standard.
What results are realistic, and how long before I notice anything?
Results are variable. Some men report less pain or a softer plaque within weeks; others notice no change in curvature. Any change in the angle of curvature tends to be gradual over three to six months, if it occurs at all, and the natural course of Peyronie's disease can improve, stay the same or worsen without treatment, which makes it hard to tell what is due to the injections. Be wary of before-and-after photographs: they rarely show the same angle, erection state or lighting. A good clinic will measure the curvature before and after, record your pain and function, and discuss what to do if there is no benefit.
Your trip to Turkey and recovery after PRP with HA
Each injection visit is short and you can walk out the same day. Expect mild pain, swelling or bruising at the site for a few days, and avoid sex and strong exercise for the period the doctor advises, often a few days. Because a course normally needs several sessions weeks apart, a single trip rarely covers the full protocol; ask whether the plan involves one visit, repeat trips or injections with a doctor at home using the same protocol. Many men travel for a consultation and the first session, staying three to four days. Do not use traction or other devices unless the urologist has explained how.
What are the risks of PRP with HA for Peyronie's disease?
PRP uses your own blood, so allergic reaction is uncommon, but injections can cause pain, bruising, swelling, infection, a small blood collection under the skin and, rarely, nerve irritation or scarring. Injecting hyaluronic acid carries the risks of any filler, including a lump or an inflammatory reaction. Because the treatment is not established, the main risk is delay: waiting for injections may postpone a treatment with stronger evidence, particularly if the curve is severe. The NHS and the AUA advise seeing a urologist for diagnosis and a discussion of all options. Also stop and seek care if you have severe pain, fever, redness, or if you cannot pass urine after an injection.
How to choose a urologist and clinic, and red flags
Choose a urologist or andrologist who sees Peyronie's disease regularly and can describe the evidence in plain terms. Ask for a written plan and price before paying a deposit. Red flags include a promise to cure or straighten the penis, claims of a guaranteed percentage improvement, no examination of your plaque, no discussion of collagenase or surgery, and treating the same plaque with unrelated products such as penis filler or penis enlargement procedures without explaining why. Read how our process works and request a plan through our free quote page.
Questions to ask the clinic:
- Is my Peyronie's disease active or stable, and what is my curvature?
- How many sessions are planned, and what does the whole course cost?
- What evidence supports this treatment, and what are the alternatives?
- Do you measure curvature and pain before and after, and share the results?
- What follow-up do I need, and who provides it when I am home?
Conditions treated with PRP with HA for Peyronie's Disease
Hospitals with Urology in Turkey
Frequently asked questions
It is an injection of platelet-rich plasma, made from your own blood, mixed with hyaluronic acid and placed in or around the Peyronie's plaque. It is meant to soften scar tissue and reduce inflammation but is not a standard treatment.
Evidence is limited. Small studies suggest some men have less pain or a smaller plaque, but trials are small and often lack controls, so results are uncertain. Professional urology guidelines do not list PRP as a standard treatment.
Approximate ranges are €300 to €1,500 per session in Turkey, against about €600 to €2,500 in the UK. The total depends on the number of sessions, so ask for a written quote for the whole course.
It cannot be promised. Some men notice a small change in curvature over three to six months, others none. For a stable, significant curve, collagenase injections or surgery have stronger evidence.
Clinics often use a course of several sessions spaced weeks apart, but there is no agreed standard. Ask what your protocol is, how success is measured and whether you must return.
The area is numbed first, and most men feel pressure and mild pain during the injection. Soreness, swelling or bruising can last a few days and usually settles without treatment.
You can usually go home the same day. Expect mild swelling for a few days and avoid sex and strenuous exercise as long as the doctor advises, often a few days.
Collagenase has stronger evidence and FDA approval for curvature over 30 degrees with a palpable plaque, while PRP is still investigational. The choice depends on your phase, curvature and priorities, so discuss both with a urologist.
A consultation and first session can fit into about three to four days. Because a full course needs several sessions weeks apart, ask whether the plan involves repeat trips or injections at home.
PRP uses your own blood, so allergic reactions are uncommon, but injections can cause pain, bruising, infection or lumps. The main concern is delaying treatments with better evidence, so see a urologist for a full assessment first.
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